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Peptic Ulcer Disease

Practice this case based on how you are assessed in your OSCEs, and use the relevant sections for general revision. 🤓

 

Doctor Instruction:


You are a Foundation Year 2 Doctor working in General Practice. Your next patient is Richard Graham – a 46-year-old male presenting with abdominal pain. Please take a history and perform a relevant examination.



 

Patient History:


You started to experience pain 2 weeks ago, and it has gradually worsened. You experience a sharp pain affecting the upper regions of your tummy (left + right + central). It comes suddenly on + off. You rate the pain as 6/10. It usually comes on when you eat any food. Pain does not radiate.


You have lost your appetite because of the pain and have been eating less than usual. You have lost some weight – you think this is because you have been eating less than usual but are unsure how much you have lost. You are always tired – you often sleep all day and do nothing significant.


No fever/dysphagia/ jaundice/ vomiting/ acid regurgitation/ early satiety/ bloating/diarrhoea/ nocturnal cough/ hoarse voice


Only mention if asked specifically: You have noticed tarry looking black stool after going to the toilet. No fresh blood can be seen.


Ideas, Concerns, Expectations:

  • You think it may be cancer because your father had colorectal cancer – you remember your dad had similar symptoms in the past. You are very worried that you have cancer. You don't know how to cope and are very scared of surgery. However, you want to find out what exactly is happening and seek as many treatment options as possible. Ask the doctor if this is cancer.


Past Medical History:

  • Arthritis + diabetes (do not know which one for both)


Drug History:

  • Metformin + ibuprofen (for joint pain)

  • NKDA


Family History:

  • Father has colorectal cancer, mum has both osteoarthritis and rheumatoid arthritis


Social History:

  • Ex-smoker – used to smoke ten cigarettes daily for ten years

  • Drinking three cans of lager daily

  • Part-time car mechanic

  • Live with your wife, who looks after you, but you are fully independent at home.

  • You currently also have three children who live nearby.


 

Examination Findings:

  • Central cyanosis/ pale conjunctiva

  • Tenderness in the epigastric region

  • PR may show melena


 

Differentials:

  1. Peptic Ulcer Disease (melena, abdominal pain pattern, NSAID use)

  2. GORD (abdominal pain + SH)

  3. To rule out Upper GI Cancer (melena, weight loss + FH)

  4. Biliary Colic (abdominal pain following eating)


 

Investigations:


Bedside:

  • PR examination, if not yet done

  • Observations

  • H pylori testing: Urea breath test, stool antigen test

  • Calculator Blatchford risk score


Bloods:

  • FBC – due to upper GI bleeding

  • U&E (baseline)

  • LFT (rule out liver pathology)

  • Iron Studies (due to bleeding)

  • Coagulation Screen (due to bleeding)

  • Group + Save +/- Cross-match


Imaging/Special Test:

  • Consider CT if the diagnosis is uncertain/uncontrolled bleeding (malignancy, ischaemia, diverticulitis...etc.)

  • Endoscopy +/- rapid urease test (CLO test) +/- biopsy to rule cancer

  • Oesophageal manometry + ambulatory PH monitoring (GORD)


 

Management:

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